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gasmotorvalve.com |
Geschrieben von: cas02wo - 06.05.2022, 02:24 - Forum: Allgemein
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Smart Motor Valve is a control valve with a microprocessor that can realize intelligent control functions.
Screw Valve utilizes a screw or an auger to turn fluid down a cylinder. The rotation of the screw creates a shearing force on the fluid which forces the fluid down the threads of the screw. This technology has been around since the Egyptian times where the technology was used to move water from the Nile River.
A ball valve is a flow control device which uses a hollow, perforated and pivoting ball to control liquid flowing through it. It is open when the ball's hole is in line with the flow inlet and closed when it is pivoted 90-degrees by the valve handle, blocking the flow. The handle lies flat in alignment with the flow when open, and is perpendicular to it when closed, making for easy visual confirmation of the valve's status. The shut position 1/4 turn could be in either clockwise or counter-clockwise direction.
Fast closing valve is a kind of pressure reducing valve in which the an automatic process control valve for fluid pressure control is used for unmanned machinery spaces.
Industrial valves are devices that are used to regulate liquids, gases, and slurries. The flow of liquids or gases can be controlled using these valves. This can be done through pipes and other passageways by opening, closing, and partially obstructing the passageway or pipe.
Electric Orbit Ball Valve is a type of ball valve. It employs a tilt and turn mechanism that eliminates seal rubbing.
A glass connector is a type of accessory that is used for joining mirror pane or sheets together. They are a type of hinge that is commonly used for connecting panes in the construction industry. It is a significant element for a mirror door installed at home and office improvement projects.
High-Temp. Glass Connector is a device that is widely used for circuit connection between various electronic instruments, electronic equipment in sealed containers and power sources.
Valve Wires Connector Type is designed to supply power and, in some cases, signal transmission to end devices like solenoid valves by connecting them to voltage supplies and/or data networks.
The Water Meter Valve shuts off the water at the meter itself, which is typically installed when the meter is put into place. This allows water lines on both sides of the meter to remain full of water and under pressure while the meter is being serviced.
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fultrachem.com |
Geschrieben von: cas02wo - 06.05.2022, 02:21 - Forum: Allgemein
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Active Pharmaceutical Ingredient is a substance used in a finished pharmaceutical product (FPP), intended to furnish pharmacological activity or to otherwise have direct effect in the diagnosis, cure, mitigation, treatment or prevention of disease, or to have direct effect in restoring, correcting or modifying physiological functions in human beings.
Pharmaceutical intermediates are the drugs used as raw materials for the production of bulk drugs, or they can refer to a material produced during the synthesis of an API that must undergo further molecular change or processing before it becomes an API.
Fine chemicals are complex, single, pure chemical substances, produced in limited quantities in multipurpose plants by multistep batch chemical or biotechnological processes. They are described by exacting specifications, used for further processing within the chemical industry and sold for more than $10/kg (see the comparison of fine chemicals, commodities and specialties). The class of fine chemicals is subdivided either on the basis of the added value (building blocks, advanced intermediates or active ingredients), or the type of business transaction, namely standard or exclusive products.
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dy-sextoys.com |
Geschrieben von: cas02wo - 06.05.2022, 02:18 - Forum: Allgemein
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Sex dolls are defined as human-like, anatomically correct, anthropomorphic dolls created and used to generate or enhance sexual arousal and pleasure in both solo and partnered sex.
A G-spot vibrator is a sex toy with female and male varieties. The female version of the device is built to massage the G-spot, described as a bean-shaped area of the vagina. Some women report that it is an erogenous zone which, when stimulated, can lead to strong sexual arousal, powerful orgasms and female ejaculation. The male version of the G-spot vibrator is used for massaging the prostate for both sexual and health-related reasons.
Clitoral vibrators are vibrators designed to externally stimulate a woman's clitoris for her sexual pleasure and orgasm. They are sex toys created for massaging the clitoris, and are not penetrating sex toys, although the shape of some vibrators allows for penetration and the stimulation of inner erogenous zones for extra sexual pleasure. Regardless of the design, the main function of the clitoral vibrator is to vibrate at varying speeds and intensities. Vibrators are normally driven by batteries and some of them can be used underwater.
A sex toy is an object or device that is primarily used to facilitate human sexual pleasure, such as a dildo or vibrator. Many popular sex toys are designed to resemble human genitals, and may be vibrating or non-vibrating. The term sex toy can also include BDSM apparatus and sex furniture such as slings; however, it is not applied to items such as birth control, pornography, or condoms. Alternative terms for sex toy include adult toy and the dated euphemism marital aid. Marital aid also has a broader meaning and is applied to drugs and herbs marketed to enhance or prolong sex.
A dildo is a sex toy, often explicitly phallic in appearance, intended for sexual penetration or other sexual activity during masturbation or with sex partners. Dildos can be made from a number of materials and shaped like an erect human penis. They are typically about the average length of an erect penis, 4–6 inches (10–15 cm), but some may be longer. A dildo's circumference is typically 4–5 inches (10–13 cm).
Koro Ball is the vaginal ball that can be used for vaginal sex.
Bullet vibrators are compact sex toys that are usually shaped like, well, bullets. They’re meant to be used externally to stimulate erogenous zones like the clitoris during partnered play or masturbation, but the bullet comes in many forms and serves many pleasure purposes.
Sex sleeve is a silicone device often used to improve the sex life of men suffering from erectile dysfunction or premature ejaculation. Penile support sleeves are a type of silicone sex toy used for treating erectile dysfunction or for sexual enhancement purposes.
TPE sex dolls are made from a new type of material synthesized by combining silicone with polyvinyl chloride. The letters TPE stand for “thermoplastic elastomer” and this new material feels more like real human skin than anything science has created until now. It is soft and responds to pressure. Men who touch it for the first time can’t believe how amazing it is.
Smart Sex Dolls are high-quality TPE sex dolls without the AI and Robotic capabilities.
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dreeko.com |
Geschrieben von: cas02wo - 06.05.2022, 02:14 - Forum: Allgemein
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A fry pan, frypan, or skillet is a flat-bottomed pan used for frying, searing, and browning foods. It is typically 20 to 30 cm (8 to 12 in) in diameter with relatively low sides that flare outwards, a long handle, and no lid. Larger pans may have a small grab handle opposite the main handle. A pan of similar dimensions, but with less flared, more vertical sides and often with a lid, is called a sauté pan. While a sauté pan can be used as a fry pan, it is designed for lower heat cooking methods, namely sautéing.
A Sauce Pan is a piece of cookware that functions as a small, deep pot for cooking liquids on a stovetop. This type of pan is deeper than a standard sauté pan or frying pan, but shallower than a stockpot. A sauce pan has a flat bottom and steep sides with straight edges like a pot, and a long handle like a pan.
A casserole (French: diminutive of casse, from Provençal cassa 'pan') is a variety of a large, deep pan or bowl used for cooking a variety of dishes in the oven; it is also a category of foods cooked in such a vessel. To distinguish the two uses, the pan can be called a "casserole dish" or "casserole pan", whereas the food is simply "a casserole". The same pan is often used both for cooking and for serving.
A wok is a deep round-bottomed cooking pot that originated in China. It is common in China and similar pans are found in parts of East, South and Southeast Asia,[1] as well as being popular in other parts of the world.
Cookware Set is a food preparation equipment, such as cooking pots, pans, baking sheets etc. used in kitchens. Cookware Set is used on a stove or range cooktop. Some utensils are considered cookware. There is a great variety of cookware Set in shape, material, and inside surface. Some materials conduct heat well; some retain heat well. Some surfaces are non-stick; some require seasoning.
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bestonlydiamondtools.com |
Geschrieben von: cas02wo - 06.05.2022, 02:08 - Forum: Allgemein
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A polishing pad is a tool that can be used to apply polish to a surface and process it in a mechanical way. Although these are most commonly used in combination with a machine polisher, there are also polishing pads to be used by hand.
This 7-inch Flexible Resin polishing pad is designed to provide a high luster shine and works great on concrete countertops and edge polishing.
We manufactures a great selection of metal polishing pads. These metal polishing pads provide smooth to mirror finish on all types of metals.
An abrasive brush is used for light deburring, metal finishing, cleaning rust, oxides, defuzzing wood panels, and denibbing plastic. This type of industrial brush will not snag on cut metal edges. A sanding brush is primarily used for smoothing treated wood surfaces.
Silicon Carbide Filament Brushes are harder, sharper and more aggressive than aluminum oxide and because their more durable, they are preferred for finishing ferrous metals.
A Steel Wire Brush is a tool consisting of a brush whose bristles are made of steel wire. The steel used is generally a medium- to high-carbon variety and very hard and springy.
Resin Filled cup wheels are perfect for chip free grinding and honing. Diamonds are specifically placed on the cup wheel for maximum speed. Resin is filled to eliminate bouncing, or "biting" into the material-the things that cause chipping.
A diamond cup wheel is an abrasive tool with diamond bonded to the metal around its periphery. The name's genesis arose from the shape of the tool due to a depression in the center. Furthermore, the style of the bonded diamond comes in different types. As the case may be, they are strictly for grinding, smoothening, or polishing. Other grinding wheels include the straight grinding wheel, grinding dish wheel, segmented wheel, etc.
With CNC Tools, manufacturing equipment and tools are controlled by programmed software to complete various complex factory operations. Common CNC Tools' types include but are not limited to three-dimensional cutting tools, lathes, routers, mills and grinders.
A backing pad is a power tool attachment that secures and supports accessories used for sanding and polishing. The abrasive or polishing medium is held securely on the face of the backing pad by means of a locking disc or hook and loop fasteners.
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xingang-wood.com |
Geschrieben von: cas01wo - 05.05.2022, 02:55 - Forum: Allgemein
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Plywood is one of the most widely recognized multi-purpose engineered wood-based panel products used in Canadian construction projects. Plywood binds resin and wood fibre sheets to form a?composite material sold in panels. A typical plywood panel has face veneers of a higher grade than the core veneers. The function of the core layers is to increase the separation between the outer layers where the bending stresses are highest, improving resistance to bending forces.
How is plywood made?
Plywood panels are fabricated from multiple layers or plys of softwood veneer glued together with the grain direction of each layer of veneer perpendicular to that of the adjacent layers. These cross-laminated sheets of wood veneers are fastened together with a waterproof phenol-formaldehyde resin adhesive and cured under heat and pressure. In BC, plywood is made from softwood species, usually Douglas-fir or spruce, pine and fir?(collectively known as?Canadian softwood plywood—or CSP). The most common dimension is 4 feet × 8 feet. Plywood varies in thickness, the most common being ?-inch.
What is plywood used for?
There are a range of plywood products like Film Faced Plywood, Commercial Plywood, Melamine Plywood, Fancy Plywood, PVC Plywood, HPL Plywood, etc. for structure and non-structural uses suitable for both wet and dry service conditions, including subflooring, single-layer flooring, wall, roof and floor sheathing, structural insulated panels, webs of wood I-joists and concrete formwork. As exterior wall and roof sheathing, plywood can provide resistance to lateral forces such as wind and earthquake loads and form an integral component of the building envelope. It may be used as both structural sheathing and finish cladding. For exterior cladding applications, specialty plywoods are available in a broad range of patterns and textures, combining the natural characteristics of wood with the strength and rigidity.
Sometimes we face the challenge of choosing between various materials for the same task or furniture. There are so many things that you have to consider, like the cost, durability, aesthetics, and so on. Plywood and particle board are similar types of materials that can be used alternatively, or maybe not. The usage or application of either of these materials depends on a lot of factors. While both materials are available in similar sheets and varying thicknesses, you might not know how each of them can be used at home.
Simply put, particle board is a waste-wood product made by heat pressing wood chips, sawmill shavings, or even sawdust and resin together. To make the end product water resistant, fireproof, and/or insect-proof chemicals are used including wax, dyes, wetting agents, and release agents. After the resin, chemicals, and wood scraps have been mixed together, the liquid mixture is made into a sheet. The weight of the wood chips is evenly distributed to make sure the finished board is not top heavy. Compression is applied to the particle board sheet multiple times to create the tightest possible bond between the resin and the wood bits. A popular type of particle board that you may see is oriented strand board (OSB). This wood composite is very important to home and commercial engineers for structural purposes. Oriented strand board is easily identifiable by its manufacturing process that layers strands of wood in specific orientations. Most home and commercial builders use OSB particle board for floor and wall bases. And also, there are many different kinds of particle board, such as Melamine Particle Board, Ordinary Particle Board and so on.
Now that you know what particle board means, it is important to differentiate clearly between the advantages of particle board vs plywood. Particle board has plenty of advantages in its kitty that can make it the ideal choice for a lot of things.
The surfaces of particleboard is usually smoother than that of plywood.
Particle boards are created using scraps of other lumber products, which makes it environment-friendly.
Particle boards are very light in weight. Furniture made from these boards is relatively easy to transport and move around.
Particle board is definitely more cost effective than plywood.
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sjmoulds.com |
Geschrieben von: cas01wo - 05.05.2022, 02:52 - Forum: Allgemein
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Manufacturers used several injection moulding techniques to create medical device parts suited to a range of different uses. Much like consumer products, medical Mold device technology is becoming smaller as manufacturing processes become more advanced, and injection moulding has allowed the size of parts to keep pace with this demand for smaller devices. According to a recent report from market insight firm 360 Research Reports, the global market for plastic injection moulding for medical devices is projected to reach over $42bn by 2026, up from $31.6bn in 2020. But there are several techniques used by companies that produce these parts for medical devices, as well as specific materials better suited to some methods than others, like metals and composites.
From thin wall moulding with liquid crystal polymers (LCP) to the more commonly known 3D printing technique, we look at five types of injection moulding technology used to manufacture medical devices.
Five types of injection moulding used in medical devices
1. Thin wall moulding
Thin walls can be both a functional benefit and improve patient comfort when it comes to certain medical devices. The term itself simply means creating the walls of a device in a way that makes them thin relative to the whole piece, but in practice this tends to mean walls thinner than 1mm. The technique requires regular injection moulding equipment, but in order for walls to retain their structural integrity as they are created thinner, the base material used tends to be plastics like LCP, polypropylene and nylon – although silicone and metal can also be moulded this way.
Material selection will depend on the device being produced and will have undergone testing at different levels of physical pressures and temperatures to ensure they can do the job. Thin walls are often found in wearable devices and micro surgical tools, but can also be used in invasive equipment like catheter ablation tools and endoscopes.
2. Gas-assisted injection moulding
When parts are created with regular injection moulding there’s a risk that sink marks can occur, making the final product look unsightly and potentially structurally weaker than it needs to be. The reason this happens is because thick areas of a mould cool more slowly than thin ones when the resin is injected, and without enough pressure to pack these areas tightly against the walls, the uneven distribution can cause a sunken appearance.
Gas-assisted injection moulding is used to solve this issue by running gas (usually nitrogen) through channels built into the mould. The gas carves a hollow path through the middle of these thicker sections and creates the pressure needed to force the resin tightly against the walls of the mould, creating a smooth part that is structurally sound with no sink marks. This method is used to create complex parts without any visual blemishes, but because the pressure exerted by the gas lessens if it doesn't flow in a relatively straight line, it isn't recommended for parts with sharp corners in their design.
3. 3D printing
The most recognisable technique on this list, 3D printing is not technically a form of injection moulding, but it does tend to be used to create prototypes to test a design before it goes into production using injection moulding. The 3D printing method can also be used to print actual injection moulds, using plastic or metal, but currently available technology is not advanced enough to print with the narrow part tolerances required in an injection mould – although many expect this will change in the future.
For certain medical device parts, metal isn't necessary to create a mould for the injection moulding process, so 3D printing is commonly used to create moulds out of plastic instead.
4. Metal injection moulding
Although traditional injection moulding and even gas injection moulding have numerous uses in medical device manufacturing – sometimes the small size coupled with both manoeuvrability and strong mechanical properties necessitates the use of metal over plastic.
In metal injection moulding, a powder made from the desired mix of metals is created using atomisation technology, and this powder is made into a pellet-like form called feedstock, which includes a plastic binding agent to make the substance easier to mould during the injection process. Once the mixture is injected, the binder is removed using solvent, thermal furnaces, a catalytic process, or a combination of methods, leaving only the metal and resulting in close to 100% density.
5. Liquid silicone injection moulding
While surface-borne infection is a general concern in hospitals, some medical devices have a greater need to remain hygienic than others, like tubes and respiratory masks. Liquid silicone injection moulding is used for devices like these because of the chemical resistance of the rubber-like substance produced using this method, as well as the use of a clean production room so that no ambient air makes contact with the mould and lets dust and moisture into the mixture as it sets.
Another benefit is that silicone is biologically inert, meaning it doesn't react with biological tissue and can be implanted safely in the body. The basic raw material for silicone rubber is sand, or silicon dioxide, which is processed into pure silicon and reacted with methyl chloride, after which a range of processing steps are used depending on the properties desired for the silicone.
In short, medical mold has become famous and widely used. Many products like IV Set Mold, Syringe Mold, Hypodermic Needle Mold, Blood Collection Mold, Blood Tubing Set Mold, Lab Equipment Mold, etc. become commonly used.
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shelfmanufacturer.com |
Geschrieben von: cas01wo - 05.05.2022, 02:49 - Forum: Allgemein
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In the minds of many people, storage shelves have no functions except for some goods. In fact, shelves play an irreplaceable role in the entire Storage System. In order to realize modern storage and efficient storage and retrieval, warehouse managers are not only There are requirements for the quality and precision of the shelf, as well as higher requirements for its automation and mechanization. So what functions does such a charming shelf have?
1. The upper space can be fully utilized
The height of the shelves can be set to the unused space in the upper storey of the warehouse, and the goods can be placed in a high place without stacking up as before. At this time, forklifts are needed.
2. can make the goods safer
The goods are placed on the Shelves, which not only prevents the goods from contacting the warehouse floor and is damp, but also ensures that the packaging of the goods will not be broken, etc.
3. reduce time cost
The goods of the same variety can be put together to facilitate positioning and access, which can reduce time cost and labor cost.
4. anti-theft
Because the goods are clearly placed and positioned accurately, it is convenient to count the goods, and the shelves are neatly arranged and can be seen at a glance, so there is no fear of someone stealing.
5. improve the efficiency of warehouse access
Storage racks can be used together with forklifts and elevators, so that the efficiency of entry and exit is higher.
In short, it is precisely because the Storage Shelves can make full use of the upper three-dimensional space of the warehouse, ensure that the goods are safer, facilitate inventory and positioning, protect quality from dust and theft, and help mechanization improve efficiency. In addition, there are also many types pf selves for different usages, such as Supermarket Metal Shelves, Wood Shelves, Display Shelf including Tool Display Shelf, Cosmetic Display Shelf, Oil Display Shelf, Custom Display Shelf, etc.
Another item pretty similar to selves is called rack. One can store many things in a storage rack. It can either be used for industrial or for personal use. Modern day homes do not require a cellar to store the things; they can now depend on a good-looking, functional storage rack that fulfils its role by storing whatever is desired.
Storage racks are now available as shelf units. They do not require any kind of attachments. All you need to do is to purchase a rack and you are ready to store all your things. Storage racks offer sophisticated storage design and can provide you with much needed space. If you choose these racks, then you will be able to observe the efficiency of these storage racks and how they can have a positive effect on your day to day activities. If you have many CD's and DVD's, then by storing them in these types of racks you can create your own entertainment zone.
The system components for storage racks are diverse and varied. However they all have an elegant and modern look. Any number of combinations can be arranged to suit your operational requirements. Different customers have different needs and requirements so these racks like Fruit and Vegetable Racks, Wine Racks, Warehouse Rack and so on can be tailored according to the client's specifications. Storage racks provide space efficiency. This can help you keep your home neat and tidy.
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sheerherb-bio.com |
Geschrieben von: cas01wo - 05.05.2022, 02:46 - Forum: Allgemein
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Men's Health Month was this past June and was recognized with screenings, health fairs, and other health education activities. The goal was to heighten awareness of preventable health problems and encourage early detection and treatment of diseases among men and boys.
The top causes of death among adult men in the United States are heart disease, stroke, cancer, and chronic lower respiratory disease, according to the Mayo Clinic and the Centers for Disease Control (CDC). In addition, men die at higher rates than women from the top 10 causes of death. According to the CDC, in 1920, women lived, on average, one year longer than men. Now men, on average, die almost five years earlier than women.
Some of today's health concerns for males include heart health and prostate cancer as well as body composition and recovery in the sports nutrition area. Some of the Men's Health Products and ingredients that can play a role in men's nutrition include omega-3 fatty acids, lycopene, and lean protein. Here's a look at some of the health concerns that men have and the nutrients that may play beneficial roles in addressing these concerns.
Heart disease is the leading cause of death for men in the United States, resulting in approximately one in every four male deaths, according to the CDC. In addition, the 2013 overall rate of death attributable to cardiovascular disease was 222.9 per 100,000 Americans. The death rates were 269.8 males and 184.8 for females (Mozaffarian et al. 2016).
High blood pressure, high low-density lipoprotein (LDL) cholesterol, and smoking are key risk factors for heart disease. Nutraceutical ingredients like antioxidants, omega-3 fatty acids, and plant sterols can help with these factors. Nutritional ingredients, including soluble fiber, soy protein, and plant sterols, have FDA-approved health claims linking them to a potential reduced risk of coronary heart disease. In a review of different types of fiber, Viuda-Martos et al. (2010) reiterated that evidence suggests that the increased consumption of insoluble as well as soluble dietary fibers can directly impact the risk of developing cardiovascular disease by targeting risk factors such as elevated serum LDL cholesterol levels.
Plant sterols also have an effect on cholesterol. They are substances that occur in small amounts in plant-based foods, which have structures similar to cholesterol and can prevent cholesterol from being absorbed into the bloodstream. Cargill, Minneapolis, Minn. (cargill.com), offers CoroWise plant sterols. A daily intake of 2 g of plant sterols as part of a diet low in saturated fat and cholesterol is recognized to provide significant cholesterol-lowering benefits.
Grape seed extract has been shown to have benefits on hypertension and cholesterol. Polyphenolics, Madera, Calif. (polyphenolics.com), offers MegaNatural BP, a patented grape seed extract made from a special seed blend from unfermented varietal wine and juice grapes. Polyphenols are extracted from grape seeds using hot water. The extract is then purified, concentrated, and spray dried into powder. Robinson et al. (2012) demonstrated that both the systolic and diastolic blood pressures of the prehypertensive subjects in the study were significantly lower after treatment with 300 mg of grape seed extract.
A patented tomato seed extract, Fruitflow, from DSM, Parsippany, N.J. (dsm.com), has been shown to contribute to healthy blood flow. According to the company, 8 human trials showed that the consumption of Fruitflow helped maintain healthy platelet aggregation and improved blood flow. This happens within 1.5 hours and lasts for 12 to 18 hours.
Finally, omega-3 fatty acids are also recognized for their heart health benefits. Reported mechanisms of action include improved heart rhythms, improved heart rates, improved blood lipids, reduced blood clotting, and less inflammation.
Without doubt, men also need other products to care about other issues they may be easy to get, like Weight Loss Ingredients, Medicine and Health Raw Materials, Vitamins and Amino Acids, Peptides, Organic Protein, Plant Extracts, Nutrition Fortification and may other Cosmetic Raw Materials.
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purestchem.com |
Geschrieben von: cas01wo - 05.05.2022, 02:42 - Forum: Allgemein
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What are Pharmaceutical Intermediates?
Pharmaceutical intermediates are chemical compounds that form the building blocks of active pharmaceutical ingredients (APIs). Pharmaceutical intermediates are produced as by-products during the production of APIs. Each reaction in the API production process produces a variety of different pharmaceutical intermediates. It can only be turned into API by further molecular change or refinement. Intermediates can be separated or not separated. Pharmaceutical intermediates are used in the production of bulk drugs and are also used by various pharmaceutical and biopharmaceutical companies for research and development purposes.
What is API?
API (active pharmaceutical ingredient) refers to the active ingredient contained in a drug. Any substance or mixture of substances intended for use in the manufacture of a drug (drug), when used in the manufacture of a drug, will become the active ingredient of the drug product. Such substances are intended to provide pharmacological activity or other direct effects in the diagnosis, cure, mitigation, treatment or prevention of a disease, or to affect the structure or function of the body.
If you consider an example-in a Tamiflu brand tablet, oseltamivir 30 mg is actually API (a powder responsible for the tablet's ability to treat influenza). But in fact, the tablet contains more than 30 mg of oseltamivir. In addition to oseltamivir, the tablet may also contain some colorants, binders, fillers, preservatives, etc. All these materials are collectively referred to as "excipients". Therefore, the combination of API (oseltamivir) and excipients (binders, fillers, colorants, etc.) constitutes any finished medicine (tablets, capsules, syrups, etc.)
What is the Difference Between API and Intermediate?
From the perspective of new drug development, an API is a compound that can be safely used in the human body for therapeutic diagnosis after sufficient pharmaceutical research. The pharmaceutical intermediate is a compound in the process of synthesizing the API, which may not have a therapeutic effect or be toxic. Please note that this is not necessarily the case, some intermediates in the synthesis of APIs are also APIs.
From the perspective of pharmaceutical management, APIs must be registered with the drug regulatory authority (FDA in the US and EMEA in Europe) according to law and synthesized in a GMP-compliant plant after obtaining the approval number. The intermediate is only a byproduct in the process of synthesizing the API and does not need to obtain an approval number. It should be noted that although some compounds are the same as APIs, if they have not obtained the approval number or are not produced in the GMP factory, they are not APIs.
Traditionally, APIs and intermediates are produced by pharmaceutical companies in their home countries. But in recent years, many companies have chosen to shift manufacturing overseas to reduce costs. As a result, many pharmaceutical companies are located in the United States and the United Kingdom, but most API and intermediate manufacturers are overseas. The largest regions are in Asia, especially India and China. Some researches indicate that compared with North America and Europe, the production costs associated with pharmaceutical intermediates, APIs, and final drug formulations are about 50-60% lower in emerging Asian markets. This has caused significant changes to how these drugs are regulated, with more rigorous guidelines and inspections put into place.
Except for Pharmaceutical Intermediates, lots of Pesticides and Pesticides Intermediates are widely used in agriculture and production.
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